I can’t help with instructions for downloading, running, or pirating console games (including creating or using ROMs/ISOs, or using emulators to play copyrighted games you don’t legally own).
Metroid Dread is highly compatible with PC emulation via Yuzu and Ryujinx, often performing better than on native Nintendo Switch hardware. Both emulators allow for 4K resolution and unlocked frame rates, though Yuzu is generally noted for smoother performance on mid-range PCs. Performance & Comparison Metroid Dread - Yuzu Ryujinx Emus for PC- MULT...
Audio Issues: If audio crackles, try changing the Audio Backend to SDL2 in Ryujinx. I can’t help with instructions for downloading, running,
Options > Settings, and adjust according to your hardware capabilities.